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hematology differential algorithm blood intravascular product reactions rheumatology ascorbicacid coagulation common cryofibrinogenemia cvid disseminated extravascular hemolytic hypogammaglobulinemia immunodeficiency immunology leukemia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... intravascular coagulation (DIC ... thrombocytopenic purpura ... usually IgM) (e.g. primary ... #hematology #anemia
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Diagnosis Framework ... /Quantity: • Primary ... : ITP • Secondary ... /TTP/HUS - Hemolytic ... anemia - Splenomegaly
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... - Differential Diagnosis ... Reticulocytosis • Primary ... Hypersplenism • Secondary ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... iron deficiency, hemolysis ... Post-splenectomy Primary ... #Causes #hematology
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Abnormalities in primary ... or secondary hemostasis ... fulminans - DIC ... #dermatology #physicalexam
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Petechiae • Purpura ... Treatment: • Treat primary ... cause • Correct ... #Coagulation #diagnosis ... #management #hematology
Scurvy (Vitamin C Deficiency) - Diagnosis and Management Vitamin C is required for hydroxylation of proline residues
Deficiency) - Diagnosis ... and Management ... contribute to nonimmune hemolysis ... , or any other cause ... • DIC • Rocky
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
pain, dark urine, DIC ... Post Transfusion Purpura ... Causes purpura & ... #Transfusion #diagnosis ... #management #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Primary (essential ... Skin necrosis • Purpura ... Cryofibrinogenemia Diagnosis ... cryoglobulins • Negative causes ... skin necrosis • DIC
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
pain, dark urine, DIC ... Post Transfusion Purpura ... Causes purpura & ... #Transfusions #diagnosis ... #management #hematology
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