11 results
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Pruritus - Generalized ... Systemic and Primary Causes ... BUN: • Chronic renal ... Myelodisplastic syndrome ... #dermatology #Differential
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... - APLS • Acute ... Gardner-Diamond syndrome ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... - ACS, AKI, acute ... : • Pathophysiology ... diagnosis #management #hematology
Hydroxychloroquine - Risks and Benefits in Lupus
Benefits:
↓ Disease activity, ↓ Flare, ↓ Damage, ↓ Corticosteroid dose,
SSA-associated fetal ... - Cuteanous: acute ... generalized exanthematous ... Benefits #Lupus #pharmacology ... #sideeffects #rheumatology
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
Edema in 70% of cases ... • SJS/TEN • Acute ... Generalized Exanthematous ... SinaiBmoreIMRes #DRESS #Syndrome ... #dermatology #diagnosis
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Renal Failure ... Differentiation #Syndrome ... diagnosis #management #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm

Blood Glucose:
 • Diabetes Mellitus
Liver Function Tests/Enzymes:
BUN: • Chronic renal ... Myelodisplastic syndrome ... secondary #systemic #generalized ... #dermatology #Differential ... Diagnosis #Algorithm #causes
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
malignancy (Especially acute ... protein C and S Pathophysiology ... Bleeding (64%) • Renal ... Treat primary cause ... treatment #management #hematology
Primary Dermatological Lesions
Primary lesions are physical changes in the skin considered to be caused directly by
considered to be caused ... scale following acute ... lesions or part of a generalized ... WEAL: an area of dermal ... #Diagnosis #Dermatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
changes (POEMS syndrome ... cancers, HCC, renal ... gastric tumors • Hematology ... inflammation (acute ... differential #diagnosis #hematology