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diagnosis hematology oncology differential management monoclonal activation algorithm behcet causes chronic clinical cll disease erythematosus gammopathies gammopathy gap globulin lupus
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... capillary leak syndrome ... • Schnitzler syndrome ... #Significance #MGUS ... Differential #Diagnosis #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Leukemia, Tumour ... Autoimmune • ITP • SLE ... Non-lmmune: • HELLP Syndrome ... Algorithm #Causes #Hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... • MGCS • MGRS ... capillary leak syndrome ... vascular beds-renal ... Paraproteinemias #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... • Tumor lysis syndrome ... lymphocytic lymphoma (SLL ... Lymphocytic Lymphoma (SLL ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... non-Hodgkin lymphoma SLL ... • Richter’s Syndrome ... • Sezary syndrome ... workup #oncology #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... Associated - SLE ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome ... Oral aphthae : SLE ... tears, Ischemia, Leukemia ... • Arthritis: SLE ... signs #symptoms #rheumatology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
dL the ULN R - Renal ... plasmacytoma, POEMs syndrome ... #Gammopathies #MGUS ... #diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... APLA/LAC: • Renal ... Hodgkin lymphoma and leukemia ... Erythematosus #Diagnosis #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... lymphadenopathy • Central ... erythematosus [SLE ... Diagnosis #Management #Hematology ... #Rheumatology
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