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diagnosis erythematosus hematology systemic activation agitation criticalcare delirium differential hcq hydroxychloroquine icu levels macrophage measurement monoclonal oncology pad pain paraproteinemias
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MGCS • MGRS ... myopathy • Anti MAG ... to cold IgG • Lupus ... vascular beds-renal ... Paraproteinemias #Hematology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... severe disease & renal ... #Systemic #Lupus ... Summary #diagnosis #rheumatology ... #management
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... Special cases (e.g. renal ... #rheumatology # ... pharmacology #levels ... #lupus #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Systemic lupus ... SJIA], systemic lupus ... erythematosus [SLE ... #Diagnosis #Management ... #Hematology #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... erythematosus (NPSLE): • May ... APLA/LAC: • Renal ... Erythematosus #Diagnosis #Rheumatology
Pain, Agitation, and Delirium (PAD) in the ICU Addressing the ICU Triad (PAD) can be accomplished through
Propofol infusion syndrome ... , bradycardia. renal ... May see this used ... No pharmacologic ... CriticalCare #diagnosis #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Xerostomia • Dental ... lubricants • Pharmacologic ... #Rheumatology # ... Diagnosis #Management
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
: • SLE • RA - ... • MAGIC syndrome ... Heart failure • Renal ... Polychondritis #rheumatology ... #diagnosis #management
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