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diagnosis rheumatology vasculitis comparison management signs table activation ana antibodies antinuclear autoantibodies compared cryoglobulins dermatology druginduced erythemas macrophage mas mimickers
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Classification: ... rash • Erythematous ... lupus erythematosus ... #Systemic #Lupus
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... • Autoimmune diseases ... vasculitis • Hypersensitivity ... lupus erythematosus ... #classification
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... 69% - Malar rash ... #Systemic #Lupus ... autoantibodies #signs #symptoms ... #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
lupus erythematosus ... lupus erythematosus ... lupus erythematosus ... (SLE), Systemic ... : Lupus (SLE), Systemic
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... of Systemic Lupus ... #SLE #systemic ... #erythematosus # ... signs #symptoms
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Constitutional symptoms ... months to years) Systemic ... Lupus Erythematosus ... Evolution: Chronic disease
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
mucositis - Rash ... lupus erythematosus ... Symptoms (Sx) in ... vasculitis, and SLE ... #classification
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... Petechial or purpuric rash ... lupus erythematosus ... [SLE], AOSD) • ... • Drug-induced hypersensitivity
Erythemas Summarized Erythema ab igne • A dermatosis that results from repeated exposure to heat (fires, heating
Erythema ab igne • A dermatosis ... form of delayed-type ... hypersensitivity ... presenting with erythematous ... comparison #table #differential
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, such as SLE, atherosclerotic ... ischemia • Skin: Erythematous ... , mucositis • Rash ... / ANCA + MPO) Cryoglobulinemic ... inflammation Hypersensitivity
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