10 results
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
Abnormal APTT Step ... of Prolonged APTT ... #APTT #prolonged ... #diagnosis #hematology ... #studies #PTT
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
PTT, Normal PT ... PTT, Normal PT ... Differential #Diagnosis ... #Algorithm #Causes ... #Hematology #coagulation
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
PT and/or aPTT ... PT and aPTT 1. ... #PT #aPTT #Prolonged ... #Causes #diagnosis ... hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
PT and aPTT If ... the PT and the ... aPTT are both prolonged ... #PT #aPTT #Prolonged ... hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
PT/NORMAL PTT: ... PT/ABNORMAL PTT ... PT/NORMAL PTT: ... PT/ABNORMAL PTT ... #Diagnosis #Hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
PT/PTT • Low ... Fibrinogen: ↓ • PT ... INR < 2.3 - APTT ... #causes #treatment ... #management #hematology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... is prolonged, but ... mixing study (aPTT ... PT/INR & von Willebrand ... #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory Evaluation ... be performed PT ... , PTT, and fibrinogen ... differential - ... #Workup #Hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... months to years) Systemic ... Lupus Erythematosus ... comparison #table #rheumatology ... #diagnosis #management
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Diagnosis: • Systemic ... ischemia • Skin: Erythematous ... fluid (CSF) is abnormal ... often causes arthritis ... #Diagnosis #Rheumatology