10 results
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Photosensitivity, Alopecia ... Workup: - ANA ... #Systemic #Erythematosus ... #Summary #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
Clinical Domains:
 • Constitutional domain: Fever
 • Cutaneous domain: Non-scarring
Lupus Erythematosus ... : Non-scarring alopecia ... pericarditis • Hematologic ... #Lupus #Erythematosus ... #diagnosis #rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... Mnemonic C - Cryoglobulinemia ... Lupus Erythematosus ... Mnemonic #diagnosis #differential ... #hematology
Allopecia - Differential Diagnosis Framework for Hair Loss

Localized / Focal Hair Loss Pattern:
 • Scarring Alopecia:
Allopecia - Differential ... Disease: Discoid lupus ... erythematosus, ... : Lupus erythematosus ... Vitamin D levels Systemic
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Differential ... lupus erythematosus ... #Lupus #Erythematosus ... #Diagnosis #Rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
months to years) Systemic ... Lupus Erythematosus ... Photosensitivity, Alopecia ... #sle #comparison ... #table #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... • Low serum C4 complement ... lupus erythematosus ... diagnosis #types #classification ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
often causes arthritis ... lupus erythematosus ... against MPO • Complement ... #diagnosis #rheumatology ... #classification
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Allergen-specific lgE causes ... glomerulonephritis, Systemic ... lupus erythematosus ... Examples: Contact dermatitis ... #comparison
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... ischemia • Skin: Erythematous ... often causes arthritis ... + MPO) Cryoglobulinemic ... #Diagnosis #Rheumatology