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2021 ACR/VF Guidelines for Management of Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA)

#Granulomatosis #Polyangiitis #GPA
Polyangiitis (GPA ... #Polyangiitis #GPA ... #MPA #ACR2021 # ... Management #rheumatology ... #algorithm #vasculitis
Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021
Polyangiitis (GPA ... ) - ANCA Vasculitis ... Management Algorithm ... #MPA #ANCA #Vasculitis ... #algorithm #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
(C-ANCA): GPA > ... >> MPA > eGPA • ... MPO-ANCA (P-ANCA ... ): eGPA, MPA >>> ... #rheumatology
Vasculitis Management - ACR/VF 2021 Guidelines for Treatment & Management
 • Giant Cell Arteritis (GCA)
 •
Vasculitis Management ... Polyangiitis (GPA ... ), Microscopic Polyangiitis ... #ACR2021 #Guidelines ... #algorithm #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
> PR3 60% • GPA ... Vasculitis: + MPO-ANCA ... (Dx: GPA, EGPA, ... differential #diagnosis #rheumatology ... #classification
ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
inflammation: • Microscopic ... polyangiitis (GPA ... polyangiitis (eGPA ... #diagnosis #algorithm ... #rheumatology
Eosinophilic Granulomatosis with Polyangiitis (EGPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021 Guidelines
 • Active
) - ANCA Vasculitis ... Management Algorithm ... #Vasculitis #Management ... #Treatment #ACR2021 ... #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic ... (e.g. systemic lupus ... diagnosis #types #classification ... #rheumatology #
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
myeloperoxidase (MPO-ANCA ... )): Microscopic ... progressive) EGPA ... > PR3 60/ GPA ... Differential #Diagnosis #Rheumatology