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Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... - Purpura - Skin ... : • Clinical triad ... Henoch-Schönlein purpura) • Cutaneous ... (e.g. systemic lupus
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
Infectious manifestations ... Neutrophilic dermatosis ... (dermatomyositis ... #differential # ... #oncology #clinical
MIAMI Mnemonic for Differential Diagnosis of Lymphadenopathy
Malignancies
 - Kaposi sarcoma, leukemias, lymphomas, metastases, skin neoplasms
Infections
 -
lymphomas, metastases, skin ... Bartonella), chancroid, cutaneous ... toxoplasmosis Autoimmune ... arthritis, Sjögren syndrome ... disease, systemic lupus
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Palpable Rash: - Autoimmune ... Vasculitis (lupus ... immunoglobulins & cryoglobulins ... • Skin biopsy
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... 3rd Decade Skin ... Differential ... Still disease, dermatomyositis ... fibromyalgia) • Infections
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... to exclude are infections ... C-ANCA) pattern: antibodies ... Serologies for Cryoglobulins ... differential #diagnosis
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Cold Agglutinin Syndrome ... Clinical Presentation ... presentation) • Cutaneous ... younger pts) Differential
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Most common extra cutaneous ... Causes: - Idiopathic ... multiforme - Dermatomyositis ... Leukocytoclastic vasculitis ... - Lupus - Leukemia