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hematology causes anemia dermatology management algorithm pulmonary purpura thrombocytopenia abscess aortitis behcet bruising cryofibrinogenemia cryoglobulinemia cryoglobulins dermatologic erythematosus extravascular gpa
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Disease ... Agglutinin Syndrome ... Diagnosis: • hemolytic ... #agglutinin #disease ... #hematology #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... usually IgG) (e.g. lupus ... agglutin disease ... Extravascular #Causes #differential ... #diagnosis #hematology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... Vasculitis Vasculitis ... infectious diseases ... - systemic lupus ... #Diagnosis #Rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Agglutination - Cold ... agglutinins disease ... cardiac valve, vasculitis ... inclusions - If infection
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Aortitis: • Vasculitides ... arteritis, Cogan's Syndrome ... ANCA associated vasculitis ... (RA), Systemic lupus ... #Diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... to exclude are infections ... differential #diagnosis ... #rheumatology # ... classification
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
PALPABLE PURPURA: Vasculitis ... Leukocytoclastic vasculitis ... • Ig A vasculitis ... HCV, HBV Not Vasculitis ... #Diagnosis #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... • IgA vasculitis ... • Vasculitis ... #rheumatology # ... vasculitis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... blood loss, Acute hemolysis ... , Vasculitides, ... IBD, Celiac disease ... Kawasaki, Nephrotic syndrome
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... • Coombs (-) hemolytic ... anemia due to cold ... #Diagnosis #Oncology
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