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differential systemic antinuclear classification symptoms table behcet comparison cryoglobulinemia cryoglobulins dermatology dermatomyositis druginduced mimickers patterns types vasculitides
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
(ANA) ANA or Anti-NucIear ... Disease! ... likely it will be clinically ... : Lupus (SLE), Systemic ... #rheumatology #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... : • ANCA-associated ... Serositis Labs: • ANA ... • (-) ANA + (+ ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pain • Kawasaki Disease ... (Granulomatous disease ... atherosclerotic disease ... most important diseases ... , and SLE) • Urinalysis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... : - ANA 95-100% ... auto-immune, Infectious diseases ... sclerosis, Still's disease ... #Diagnosis #autoantibodies
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
with disease activity ... searched for when ANA ... with auto-immune diseases ... #diagnosis #rheumatology ... #table #ANA
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Workup: - ANA ... Erythematosus ( ... Workup: - ANA ... : Chronic disease ... #diagnosis #management
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... Asia • HLA-B51 association ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Systemic rheumatic diseases ... disease, drug reactions ... most important diseases ... (GRANULOMATOUS DISEASE ... HBV Kawasaki Disease
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... • Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... (e.g. systemic lupus ... erythematosus (
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
• Antibodies targeting ... had more severe disease ... three days #AntiNXP2DM ... #AntiNXP2 #Dermatomyositis ... #diagnosis #management
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