6 results
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
erythematosus ... connective tissue disease ... 90% • Anti-GBM disease ... #antibodies #diagnosis ... diseases
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Summary Cryoglobulins ... Syndrome: • Clinical ... • Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... erythematosus (
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... : The ANA patterns ... : Lupus (SLE), Systemic ... #ANA #patterns ... #rheumatology #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
(Granulomatous disease ... atherosclerotic disease ... most important diseases ... ) pattern: antibodies ... , and SLE) • Urinalysis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... : • ANCA-associated ... diseases (i.e. ... • (-) ANA + (+ ... #Diagnosis #Rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... searched for when ANA ... with auto-immune diseases ... #diagnosis #rheumatology ... #table #ANA