15 results
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
lupus erythematosus ... lupus erythematosus ... lupus erythematosus ... : Lupus (SLE), Systemic ... #rheumatology #diagnosis
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Lupus Erythematosus ... Cerebrovascular Disease ... : • Inflammatory ... #Lupus #Erythematosus ... #rheumatology #
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Auto-Antibodies ... and Lupus Mimickers ... #Systemic #Lupus ... #signs #symptoms
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
Lupus - with Systemic ... Lupus Erythematosus ... (SLE), should have ... other symptoms ... #arthropathy #arthropathies
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Classification: ... lupus erythematosus ... #Systemic #Lupus ... #Diagnosis #Rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
months to years) Systemic ... Lupus Erythematosus ... #sle #comparison ... #table #rheumatology ... #diagnosis #management
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Allergen-specific lgE antibodies ... - Local and systemic ... systemic lupus ... erythematosus Type ... #Pathophysiology
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Action: IgG/lgM antibodies ... reaction, Haemolytic disease ... glomerulonephritis, Systemic ... lupus erythematosus ... #comparison
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
as systemic lupus ... Symptoms (Sx) in ... LFT • ESR • ANA ... #rheumatology # ... classification
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Systemic lupus ... lupus erythematosus ... [SLE], AOSD) • ... Treatment: • Corticosteroids ... #Rheumatology