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differential rheumatology neurology sle systemic ana anca antibodies antibody antineutrophil antinuclear bee compared cryoglobulinemia cryoglobulins dermatology diseases erythemas hematology inflammatory
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pulmonary and renal ... tract, and often causes ... erythematosus, ... • Urinalysis (Renal ... #rheumatology #classification
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
ANCA-positive vasculitis ... ANCA-negative vasculitis ... IgA-associated vasculitis ... erythematosus, ... #nephrology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... ANCA-associated vasculitis ... • Mesenteric vasculitis ... APLA/LAC: • Renal ... inflammation Cutaneous Vasculitis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Butterfly rash, Vasculitis ... Abdominal pain (20%) Renal ... SLE #systemic #erythematosus ... signs #symptoms #diagnosis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
) • Systemic lupus ... erythematosus ... ANCA-Associated Vasculitis ... vasculitis - MPO ... Antineutrophil #antibodies #diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• IgA vasculitis ... Hypersensitivity vasculitis ... • Vasculitis ... erythematosus ( ... #rheumatology #vasculitis
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
Inflammatory causes ... syndrome • Systemic lupus ... erythematosus ... ANCA-associated vasculitides ... BEE #Syndromes #neurology
Rhombencephalitis BACTERIAL - Listeria (biphasic illness with bulbar dysfunction occurring later) - Mycobacterium tuberculosis - Pneumococcus - Brucella - Borrelia (Lyme Disease) -
Toxoplasmosis AUTOIMMUNE/VASCULITIS ... Disease - Systemic Lupus ... Erythematosus ... #Differential #Diagnosis ... #Causes #Neurology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... pulmonary and renal ... ischemia • Skin: Erythematous ... tract, and often causes ... - interstitial keratitis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Entities That Can Feature ... Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... to cold IgG • Lupus ... vascular beds-renal
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