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classification hypersensitivity reactions dermatology differential management sle systemic table treatment vasculitis angioedema arthritis bradykinin cerebritis champs cns comparison complement cryoglobulins
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
Immunological Target: Allergen ... fever, Urticaria, Allergic ... Gravis, Graves' Disease ... • Ex: Systemic Lupus ... Erythematosus,
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
Soluble antigen - Allergen-specific ... When the specific allergen ... , and systemic lupus ... erythematosus ... Pathophysiology #Allergy
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Mechanism of Action: Allergen-specific ... reaction, Haemolytic disease ... erythematosus Type ... Examples: Contact dermatitis ... #allergy #table
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Mnemonic C - Cryoglobulinemia ... Chain deposition disease ... S - Systemic Lupus ... Erythematosus ( ... CHAMPS #Mnemonic #diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... • Autoimmune diseases ... (e.g. systemic lupus ... erythematosus ( ... #rheumatology #
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus ( ... SLE) Clinical ... Cerebrovascular Disease ... #SLE #CNS #neurology ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Suspect: Clinical ... Differential Diagnosis ... Non-autoimmune rheumatologic ... • Type-I Interferonopathies ... #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
ANCA +MPO) • Cryoglobulinemic ... inflammation Others: • Lupus ... such as systemic lupus ... erythematosus, ... #rheumatology #
Moccasin-variety Tinea Pedis 70 M chronic scaly feet. Over the years: rash has itched only occasionally;
Diagnosis? ... sp. pruritic, erythematous ... dyshidrotic, atopic, or allergic ... eczematous dermatitis ... #clinical #photo
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
febrile neutrophilic dermatosis ... with systemic disease ... such as certain types ... CANDLE syndrome - Allergic ... ’s syndrome - Lupus
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