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classification antinuclear arthritis comparison management types vasculitis anca antineutrophil approach cryoglobulinemia cryoglobulins disorders druginduced erythematosus hypersensitivity joint laboratory msk pain
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibody refers ... Disease! ... : Lupus (SLE), Systemic ... #rheumatology #diagnosis ... #differential
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
connective tissue disease ... 90% • Anti-GBM disease ... #antibodies #diagnosis ... #rheumatology # ... diseases
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... • Immunologic Workup ... : - ANA > ... Evolution: Chronic disease ... #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... PT, aPTT(liver disease ... bypass), LFT (liver disease ... #Diagnosis #Causes ... #Workup #hematology
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... lgE causes mast-cell ... Action: IgG/lgM antibodies ... reaction, Haemolytic disease ... Examples: Contact dermatitis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Discontinuation of causal ... Evolution: Chronic disease ... #table #rheumatology ... #diagnosis #management
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Studies in Rheumatic Diseases ... connective-tissue disease ... #Rheumatic #Disease ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
(Granulomatous disease ... rheumatic diseases ... atherosclerotic disease ... most important diseases ... #diagnosis #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia Summary ... • Autoimmune diseases ... cytoplasmic antibody ... (e.g. systemic lupus ... classification #rheumatology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
), RA, crystal disease ... Inflammatory, crystalline disease ... Chronic = RA, SLE ... Joint #Pain #MSK #rheumatology ... #differential #
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