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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Lupusreference #Renal #diseases ... #SLE #Systemic ... #venn #nephrology ... #nephritis #classification ... #types #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... Henoch-Schönlein purpura) • Cutaneous ... lupus erythematosus ... #classification ... #rheumatology #
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
POEMS, AL amyloid, Cryoglobulinemia ... nemaline myopathy Cutaneous-centered ... immunotactoid GN, Type ... Ig deposition disease ... Differential #Diagnosis #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... • Neutrophilic dermatosis ... gangrenosum • Cutaneous ... to cold IgG • Lupus ... Paraproteinemias #Hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
lupus erythematosus ... strong sign of cutaneous ... , and SLE) • Urinalysis ... differential #diagnosis #rheumatology ... #classification
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Classification: ... • Type-I Interferonopathies ... #Systemic #Lupus ... Erythematosus #Diagnosis #Rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
, such as SLE, atherosclerotic ... Strong sign of cutaneous ... / ANCA + MPO) Cryoglobulinemic ... - interstitial keratitis ... Differential #Diagnosis #Rheumatology
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
disease. ... Most common extra cutaneous ... such as certain types ... ’s syndrome - Lupus ... Syndrome #diagnosis #dermatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... skin (xerosis) • Cutaneous ... vasculitis: 10% ... 7%, Cryoglobulinemia ... Sjogrens #Syndrome #Rheumatology