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diagnosis differential rheumatology hematology manifestations oncology skin cryoglobulins dermpath lesions monoclonal myelodysplastic nonpalpable paraproteinemias pathology purpura signs syndrome types
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
: CTD: SLE, RA related ... Vessel: Petechiae, Palpable ... Erythema elevatum ... : • Behcet Disease ... #dermatology #rheumatology
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
of Cutaneous Vasculitis ... Connective tissue disease ... (10%) : SLE +++ ... #dermatology #semiology ... lesions #diagnosis #clinical
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
PURPURA: Vasculitis ... Leukocytoclastic vasculitis ... • Ig A vasculitis ... associated small vessel vasculitis ... HCV, HBV Not Vasculitis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
triad of Palpable ... • IgA vasculitis ... small-vessel vasculitis ... • Vasculitis ... #rheumatology #vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
such as systemic lupus ... scleritis • Palpable ... strong sign of cutaneous ... , and SLE) • Urinalysis ... #rheumatology #classification
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
appearing during the disease ... Neutrophilic dermatosis ... dermatomyositis, SLE ... leukocytoclastic vasculitis ... #oncology #clinical
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
gangrenosum • Cutaneous ... leak syndrome • Erythema ... Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... to cold IgG • Lupus
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