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diagnosis differential rheumatology oncology hematology clinical cryoglobulins erythematosus monoclonal nonpalpable pain palpable paraproteinemias purpura rashes sweet systemic types
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
Cutaneous manifestations ... appearing during the disease ... Neutrophilic dermatosis ... dermatomyositis, SLE ... leukocytoclastic vasculitis
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
: CTD: SLE, RA related ... Erythema elevatum ... : • Behcet Disease ... • Cogan syndrome ... Vasculitis #skin
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Hypersensitivity vasculitis ... • Vasculitis ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... #joint #pain #skin
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis - Skin ... vesicular eruption - Joints ... such as systemic lupus ... , and SLE) • Urinalysis ... #rheumatology #classification
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• IgA vasculitis ... small-vessel vasculitis ... Hypersensitivity vasculitis ... • Vasculitis ... #rheumatology #vasculitis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
gangrenosum • Cutaneous ... • Erythema elevatum ... Autoimmunity: • -MM/WM: Vasculitis ... Hypergammaglobulinemic macular Vasculitis ... to cold IgG • Lupus
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
PALPABLE PURPURA: Vasculitis ... Leukocytoclastic vasculitis ... • Ig A vasculitis ... associated small vessel vasculitis ... HCV, HBV Not Vasculitis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Disease Classification ... ANCA-associated vasculitis ... • Mesenteric vasculitis ... Vasculitis: •
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, such as SLE, atherosclerotic ... vesicular eruption • Joints ... Palpable purpura, joint ... / ANCA + MPO) Cryoglobulinemic ... - interstitial keratitis
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... Most common extra cutaneous ... Leukocytoclastic vasculitis ... - Lupus - Leukemia ... #diagnosis #dermatology
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