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Renal Involvement in Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#Renal #diseases #SLE #Systemic #Lupus #Erythematosus #venn #nephrology
Lupus Erythematosus ... Lupusreference #Renal #diseases ... #SLE #Systemic ... #venn #nephrology ... #nephritis #classification
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... tissue disease ... (SLE), Sjogren's ... Syndrome (SS), ... (SLE), Systemic
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
ANA ≠ Autoimmune Disease ... tissue disease ... (SLE), Systemic ... • Rheumatic Diseases ... : Lupus (SLE), Systemic
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Classification of ... - Kawasaki disease ... and infectious diseases ... - serum disease ... lupus erythematosus
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... with more severe disease ... Used to monitor disease ... with more severe disease ... Treatment: • Mild disease
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
central nervous system ... and less common diseases ... Vogt-Koyanagi-Harada (VKH) disease ... • Systemic lupus ... polychondritis • Behcet disease
Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
Connective tissue disease-associated ... interstitial lung diseases ... PSS: Sjogren syndrome ... : systemic lupus ... connective tissue disease
Mucous Membrane Disorder - Differential Diagnosis Algorithm
Erosions/Ulcers/Blisters
 - Primary Dermatologic Diseases
     •
Primary Dermatologic Diseases ... Disease • ... Systemic lupus ... Inflammatory bowel disease ... more than Crohn's disease
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Differential Diagnosis Algorithm ... Cholestatic liver disease ... Myelodisplastic syndrome ... Psychiatric Disease ... Differential #Diagnosis #Algorithm
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
Inflammatory Bowel Disease ... Arthropathy with Crohn’s Disease ... autoimmune disease ... Lupus - with Systemic ... (SLE), should have