Dermatology Differential causes pulmonary pathophysiology classification diffuse disorders anemia hemolytic intravascular cold

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Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
• Mechanical Trauma (Microangiopathic hemolytic anemia):

Causes Intravascular ... anemia): ... lymphoproliferative disorders ... #Hemolytic #Intravascular ... #Causes #differential

Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
-

Causes of Extravascular ... Hemolysis - Differential ... Warm AIHA • Cold ... anemia • ... #Hematology

Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
• Enzyme deficiencies ex. G6PD, pyruvate kinase
• Hemoglobinopathies

for Hemolytic Anemia ... • AIHA: warm, cold ... IVIG infusion Intravascular ... #Anemia #Differential ... #classification

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

• Symptoms of anemia ... anemia • Cold ... younger pts) Differential ... the RBCs causing intravascular ... #anemia #hematology

Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations

Clinical Classification ... Schistosomiasis - Chronic hemolytic ... anemia - Persistent ... #Diagnosis #Differential ... #Causes

Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It

• Autoimmune disorders ... nodosum • Immune hemolytic ... anemia • Pain ... ) Classification ... Immunohistochemical studies (to differentiate

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