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Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Syndrome • ... #Syndrome #HES ... #Hematology #eosinophilia ... #eosinophils #diagnosis ... #management #algorithm
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
: • Primary hypereosinophilic ... syndromeEosinophilic ... Hyper-lgE (Job) syndrome ... histiocytosis • Allergic ... Diagnosis #Algorithm #allergy
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia ... Syndrome (HES) ... Diagnosis and Management ... Secondary Causes: - Allergic ... #management #eosinophils
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Allergies): - Allergic ... Rhinitis - Allergic ... Leukemia - Primary Hypereosinophilic ... Syndrome - Chronic ... Diagnosis #Causes #hematology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... /hypereosinophilia ... 1,500 cells/µL • Hypereosinophilia ... causes are asthma, allergy ... Differential #diagnosis #hematology
Differential Diagnosis of Pulmonary Eosinophilia
Infection:
 • Helminthic: Loffler syndrome (Ascaris, hookworm, Strongyloides), Tropical pulmonary eosinophilia (lymphatic
Diagnosis of Pulmonary Eosinophilia ... Helminthic: Loffler syndrome ... coccidioidomycosis), Allergic ... , Hypereosinophilic ... syndrome, Neoplasms
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Approach to Eosinophilic ... loss, malaise • Allergic ... , CV, renal • Hypereosinophilic ... Syndrome (> 6 mo ... differential #diagnosis #comparison
Drug Reaction with Eosinophilia and Systemic Signs (DRESS Syndrome): Formerly known as drug hypersensitivity reaction, DRESS
represents
Reaction with Eosinophilia ... Systemic Signs (DRESS Syndrome ... associated with allergic ... Images #Clinical #Dermatology ... SkinRash #DRESS #Syndrome
Drug Reaction with Eosinophilia and Systemic Signs (DRESS Syndrome): Formerly known as drug hypersensitivity reaction, DRESS
represents
Reaction with Eosinophilia ... Systemic Signs (DRESS Syndrome ... associated with allergic ... Images #Clinical #Dermatology ... SkinRash #DRESS #Syndrome
Causes of Leukocytosis and Leukopenia - Differential Diagnosis
 • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
Diagnosis • Eosinophilia ... (AEC > 500, hypereosinophilia ... > 1500): Allergic ... Diagnosis #causes #hematology