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diagnosis hematology anemia blood hemolytic product classification extravascular intravascular nonpalpable palpable taco trali transfusions vasculitis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... thrombocytopenic purpura ... reaction, Paroxysmal ... #differential # ... diagnosis #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Transfusion Reaction ... maculopapular rash ... Causes purpura & ... #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
maculopapular rash ... Purpura (PTP): ... Causes purpura & ... #diagnosis #management ... #hematology #reactions
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... fever • Drug reactions ... #Differential # ... Diagnosis #hematology
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Differential Diagnosis ... for Hemolytic Anemia ... prosthetic valve • Transfusion ... reactions ex. ... classification #hematology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
Reactions TRALI ... without other cause ... #Reactions #hematology ... #diagnosis #comparison ... #table
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... disease, drug reactions ... , mucositis • Rash ... tract, and often causes ... #Diagnosis #Rheumatology
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