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diagnosis differential management mds myelodysplastic algorithm chronic gammopathies lymphocytic mgus monoclonal multiplemyeloma myelodysplasia protein proteingap thrombocytopenia treatment workup
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Anemia • Toxic ... Leukemia, Tumour ... ITP • SLE • CLL ... Non-lmmune: • HELLP Syndrome ... #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... cytopenias (usually anemia ... Myelodysplastic #Syndrome ... Management #treatment #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... myelodysplastic syndrome ... #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... aplasia • ITP ... • Richter’s Syndrome ... syndrome • Smoldering ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Hematology #Oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
globulin gap (> ... changes (POEMS syndrome ... gastric tumors • Hematology ... anemia • Other ... differential #diagnosis #hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
40 ml/min A - Anemia ... Look for gamma gap ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology ... #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... • Anemia • Aplastic ... Cell Leukemia ... #diagnosis #hematology ... #oncology
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