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diagnosis differential management mds algorithm chronic lymphocytic myelodysplasia protein proteingap treatment workup
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Anemia • Toxic ... Leukemia, Tumour ... Non-lmmune: • HELLP Syndrome ... #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - ... cytopenias (usually anemia ... #Syndrome #MDS ... Management #treatment #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... marrow-failure syndromes ... syndrome (MDS) ... #oncology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Syndromes (MDS) ... syndromes are a ... • Anemia • Aplastic ... Cell Leukemia ... #hematology #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
, thrombocytopenia ... aplasia • ITP ... • Richter’s Syndrome ... syndrome • Smoldering ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... - infiltrates (anemia ... , thrombocytopenia ... • Tumor lysis syndrome ... #Hematology #Oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
globulin gap (> ... changes (POEMS syndrome ... gastric tumors • Hematology ... anemia • Other ... differential #diagnosis #hematology
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