11 results
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Hypersensitivity ... cellular antigen, leading ... to complement activation ... Complement activation ... #Types #Classification
Practical Approach to Grading Diastolic Dysfunction

#Diagnosis #Cardiology #Diastolic #Diastology #Dysfunction #Grading #Classification #Grades #Criteria #Algorithm #Assessment
Practical Approach to Grading ... #Dysfunction #Grading ... #Classification ... #Grades #Criteria ... #Algorithm #Assessment
Hypersensitivity: Definitions
 • Type I - Production of lgE Abs that bind to harmless allergens and
Hypersensitivity ... allergen causes development ... because T-Cell activation ... #Hypersensitivity ... #Classification
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
of hypersensitivity ... cell antigens, leading ... to complement activation ... Graft rejection #hypersensitivity ... allergy #table #classification
Type IV Hypersensitivity: Pathogenesis and clinical findings
Definition: Unique because it is entirely T-Cell mediated; exposure to
Type IV Hypersensitivity ... allergen causes development ... because T-Cell activation ... ivy) #TypeIV #Type4
Pathogenesis of Rheumatic Fever

Pathogenesis of rheumatic fever. 
1. GAS pharyngitis leads to antigenic presentation of pathogenic
gets activated leading ... to the development ... skin, and brain leading ... by endothelial activation ... Exposure of Type-IV
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
immune system, leading ... Types: • Type ... • Type III Often ... vasculitis • Hypersensitivity ... #classification
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... IL-1 and IL-6, leading ... Presentation: • Rapid development ... • Drug-induced hypersensitivity ... Histopathologic criteria
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
sympathetic + ADH activation ... Diagnosis (Clinical Criteria ... Classification: ... HRS-AKI (formerly Type ... HRS-Non-AKI (formerly Type
Monoclonal Gammopathy of Renal Significance (MGRS)

MGRS
• MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
does not meet criteria ... guide subtype classification ... Complement pathway activation ... vasculitis Types