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differential management sle symptoms systemic vasculitis activation ana antibodies antinuclear cryoglobulinemia cryoglobulins laboratory mas patterns primary rheumatic testing vasculitides
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
and Clinical Findings ... like rheumatoid ... arthritis (RA) ... #Syndrome #Pathophysiology ... #Diagnosis #Signs
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... • Rheumatic Diseases ... Arthritis, Sjögren ... ANA #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... dermatomyositis, Sjogren ... • Type-I Interferonopathies ... Clinical Features ... #Diagnosis #Rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... of hip (rare), Arthritis ... Demyelinating syndromes ... #signs #symptoms ... #diagnosis #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
: • Clinical triad ... syndrome - type ... arthritis, Sjögren's ... #types #classification ... #rheumatology #
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... erythematosus ... erythematosus [ ... #Diagnosis #Management ... #Hematology #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... erythematosus ( ... #Disease #Rheumatoid ... #workup #diagnosis ... #testing #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Syndrome Diagnosis ... salivary ducts Clinical ... phenomenon (16%) MSK ... #Syndrome #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
: Systemic rheumatic ... erythematosus, ... purpura: strong sign ... #rheumatology # ... classification
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