21 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... with thiazide diuretic ... • Metabolic alkalosis ... #Syndrome #diagnosis ... #nephrology #management
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride
 • Cl- responsive metabolic alkalosis
loop or thiazide diuretics ... pressure: Active diuretic ... use, Bartter syndrome ... , Gitelman syndrome ... #Alkalosis #Differential
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Causes of Hypokalemia ... , Bartter's syndrome ... syndrome (mimics ... #Causes #differential ... #diagnosis #nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Loop and thiazide diuretics ... , Gitelman syndrom ... #causes #potassium ... #low #nephrology
Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
Differential Diagnosis ... and Gitelman syndrome ... with secondary, hypocalcemia ... renal transplant, Diuretic ... #nephrology #magnesium
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
Loop and thiazide diuretics ... - Hypokalemia ... - Osmotic diuresis ... syndrome - ... Diagnosis #Low #
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
loop or thiazide diuretics ... : Active diuretic ... use, Bartter syndrome ... , Gitelman syndrome ... urine #Algorithm #nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation ... Before evaluating hypokalemia ... , Diuretics, Bartter ... syndrome, Gitelman ... potassium #nephrology
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... • Refeeding syndrome ... • Discontinued diuretic ... MatthewHoMD #Hypokalemia ... #nephrology #low
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Causes of Hypokalemia ... of hypokalemia ... Post-hypercapnia • Diuretics ... , Gitelman's syndrome ... #causes #nephrology