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differential management algorithm high hyperkalemia alkalosis chloride diuresis diuretics low medications pathophysiology pharmacology renal summary urinary workup
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
↓ Aldosterone: Syndrome ... excess, Liddle's syndrome ... Diuretics, Bartter syndrome ... , Gitelman syndrome ... #nephrology #low
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... Hypocalciuria (spot urine ... Treatment - ... #Syndrome #diagnosis ... #nephrology #management
Metabolic Alkalosis - Urinary Chloride Algorithm Cl- responsive metabolic alkalosis • Kidney loss of Cl-
diuretic use, Bartter syndrome ... , Gitelman syndrome ... the indicated causes ... of sodium and potassium ... #Algorithm #nephrology
Gitelman Syndrome - Diagnosis and Workup Blood Work: - Hypokalemia - Hypomagnesemia - Metabolic Alkalosis - Elevated
Gitelman Syndrome ... Blood Work: - Hypokalemia ... Elevated Renin Urine ... #Syndrome #Diagnosis ... #Workup #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Compartment syndrome ... Heat stroke - Metabolic ... Neuroleptic malignant syndrome ... or compartment syndrome ... #treatment #nephrology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
iniury, Compartment syndrome ... , Heat stroke, Metabolic ... Neuroleptic malignant syndrome ... hour with goal urine ... Monitor potassium
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
- Tumor lysis syndrome ... - Rhabdomyolysis ... infusions) - Metabolic ... #causes #potassium ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
- Tumor lysis syndrome ... - Rhabdomyolysis ... infusions) - Metabolic ... #causes #potassium ... #high #nephrology
Rhabdomyolysis - Differential Diagnosis Framework Rhabdomyolysis = Destruction of skeletal muscle with leakage of contents into circulation.
Neuroleptic malignant syndrome ... • Metabolic and ... Electrolytes: Hypokalemia ... #Causes #nephrology ... #table
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
disequilibrium syndrome ... and nephrotic syndrome ... and nephrotic syndrome ... disease • Liddle syndrome ... #Diuresis #Nephrology
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