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diagnosis management hematology hemophagocytic hlh nephrology oncology syndrome activation aosd behcet causes classification differential diuresis diuretics excretion hemeonc hodgkins lymphoma
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... • Autoimmune diseases ... : SLE+++, Adult-onset ... Still disease, ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... age, however the disease ... also observed in adults ... Ferritin >500 ng/mL ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
haemophagocytic lymphohistiocytosis ... arthritis (sJIA) • Adult-onset ... 5000 to 10,000 ng/mL ... Treatment: • Corticosteroids ... #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Epidemiology: • Young adults ... aseptic meningitis), MCC ... : Arterial (MCC-small ... Arthritis, AS Treatment ... signs #symptoms #rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... Ferritin >3000 ng/mL ... Treatment - Mild ... : NSAIDS Treatment ... AOSD #diagnosis #rheumatology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
intracranial pressure • Dialysis ... Inhibitors of Na+K+2Cl ... chronic kidney disease ... Tolvaptan) • Treatment ... #Medications #Table
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Treatment of underlying ... disease 2. ... urine output: 200 ml ... per day until stable ... Dialysis for severe
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
history • Young adults ... classical HL (MCHL ... number of sites of disease ... Hodgkin Lymphoma Treatment ... classification #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Hemophagocytic Lymphohistiocytosis ... to find in an adult ... - Common in: Adults ... ▪ Autoimmune diseases ... Hemophagocytic #Lymphohistiocytosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelogenous Leukemia (CML ... Myeloproliferative Disease ... factor (GCSF) treatments ... appear normal, but analysis ... Syndromes #diagnosis #hematology
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