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diagnosis management hematology hemophagocytic hlh nephrology activation castleman causes differential diuresis diuretics druginduced excretion lupus macrophage mas mds medications multicentric
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... • Autoimmune diseases ... Adult-onset Still disease ... Unknown cause Treatment ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... age, however the disease ... Ferritin >500 ng/mL ... • Bicytopenia Treatment ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
haemophagocytic lymphohistiocytosis ... hemophagocytic lymphohistiocytosis ... 5000 to 10,000 ng/mL ... Treatment: • Corticosteroids ... #Rheumatology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
intracranial pressure • Dialysis ... Inhibitors of Na+K+2Cl ... chronic kidney disease ... Tolvaptan) • Treatment ... #Medications #Table
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Treatment of underlying ... disease 2. ... urine output: 200 ml ... per day until stable ... Dialysis for severe
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
constitutional symptoms • Treatment ... life-threatening • Treatment ... Evolution: Chronic disease ... druginduced #lupus #sle #comparison ... #table #rheumatology
Unicentric Castleman Disease (UCD) vs Multicentric Castleman Disease (MCD) - Comparison Table Unicentric Castleman Disease (UCD): •
(MCD) - Comparison ... Table Unicentric ... biopsy, imaging • Treatment ... and response to treatment ... #Comparison #Table
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelogenous Leukemia (CML ... Myeloproliferative Disease ... factor (GCSF) treatments ... appear normal, but analysis ... Syndromes #diagnosis #hematology
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