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diagnosis hematology differential erythematosus lupus management monoclonal sle systemic aplastic chronic classification cll cryofibrinogenemia cutaneous eschar gammopathy gap globulin hodgkins
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... Mechanisms: • Direct ... Clinical Presentation ... Headaches • Pale skin ... #oncology #hematology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... Cryoglobulinemia Renal-centered ... immunotactoid GN, Type I cryo ... Differential #Diagnosis #hematology ... #oncology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Sjögrens (15%) Skin ... Restrictive lung defect ... ) Blood (75%): Anemia ... symptoms #diagnosis #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... (-) hemolytic anemia ... , retinal, DVT, ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cryofibrinogenemia Clinical ... pulmonary emboli, and ocular ... thrombi including retinal ... Diagnosis: • + Clinical ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Hepatomegaly • Skin ... • Neutropenia, anemia ... diagnosis #workup #oncology ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... Weight loss • Anemia ... Immune hemolytic anemia ... classification #hematology ... #oncology #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... 3rd Decade Skin ... Erythematous, macular ... Non-autoimmune rheumatologic ... lymphopenia, low PLT • Anemia
Cutaneous Mucormycosis Eschar 30 M HIV cd4 10 VL 30k traumatic injury of arm few months ago
mucormycosis by direct ... drug injections, renal ... trauma, aplastic anemia ... Mucormycosis #Eschar #dermatology ... #skin #clinical
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
gammopathy, and skin ... cancers, HCC, renal ... gastric tumors • Hematology ... Thalassemia, Sickle cell anemia ... differential #diagnosis #hematology
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