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diabetes agonists diagnosis glp1 management summary apml challenges comparison differentiation fluid hematology inhibitors oncology receptor responsiveness sglt2 testing tolerance
SGLT2 Inhibitors - Pharmacology Summary Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
Jardiance) - Best risk ... mortality in high risk ... Canagliflozin ↑ risk ... #Summary #DM2 # ... diabetes #endocrinology
GLP-1 Receptor Agonists - Pharmacology Summary Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1
Receptor Agonists - Pharmacology ... outcomes in high risk ... effect) • May ↑ risk ... #Summary #DM2 # ... diabetes #endocrinology
GLP-1 Agonists Adlyxin (Lixisenatide) Daily Bydureon (Exenatide ER) Weekly Ozempic (Semaglutide) Weekly Trulicity (Dulaglutide) Weekly Victoza (Liraglutide) Daily
carrying only a low risk ... GI tract) and injection ... GLP1 #Agonists #Pharmacology ... #Dosing #Diabetes ... #DM2 #Endocrinology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Attempt if high risk ... day vs. 2.5 mg/m2 ... Imaging: CXR- pulmonary ... Differential Diagnosis: Infection
Fluid Responsiveness and Fluid Tolerance Testing - OnePager Summary Fluid resuscitation can be beneficial when required or
vasopressors and lower risk ... Pulmonary Artery ... via cold saline injection ... • PULMONARY A ... testing #diagnosis #criticalcare
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