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diagnosis management differential oncology comparison embolism activation adult afib algorithm anticoagulation arterial artery autoimmune autoinflammatory bleed cancer chads2 chads2vasc classification
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
(MAS) Classified ... erythematosus [SLE], AOSD ... Histopathologic criteria ... Diagnosis #Management #Hematology ... #Rheumatology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... (MDS) Most met ... criteria for 1) ... (MDS) and/or ... Autoinflammatory #Somatic #rheumatology
CHA2DS2VASc vs HAS-BLED scores for stroke risk and bleed risk on anticoagulation C Congestive Heart Failure 1 H Hypertension 1 A2 Age >75 2 D Diabetes Mellitus 1 S2 Stroke,
CHA2DS2VASc vs HAS-BLED ... scores for stroke ... 2 V Vascular disease ... HASBLED #Comparison #Score ... AFib #Diagnosis #Hematology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Onset Still's Disease ... a sore throat, ... mL Gf consider MAS ... #AOSD #diagnosis ... #rheumatology #
Coronary Artery Embolism - Etiology and Scoring Etiology: • Direct: Clot (LV thrombus, LAA Thrombus), Valve (Vegetation,
Fibroelastoma), Mass ... Presence of embolic risk ... rheumatic valve disease ... prosthetic valve, PFO, ASD ... #cardiology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
increased infection risk ... adulthood • Diagnosis may ... : • Nephrotic syndrome ... (Epstein-Barr syndrome ... hypogammaglobulinemia #immunology #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... vein thrombosis Hematologic ... Thrombosis highest risk ... Erythematosus #Diagnosis #Rheumatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Acquired Risk ... Myeloproliferative disease ... Paget-Schroetter, May-Thurner ... • Nephrotic Syndrome ... pathophysiology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
(MDS) What? ... carries a variable risk ... Myeloproliferative Disease ... and reducing the risk ... #diagnosis #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma Risk ... Anterior mediastinal mass ... number of sites of disease ... through Ann Arbor criteria ... classification #hematology
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