Dissociation anesthesia management peds treatment disease rheumatology hlh workup diagnosis summary

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This brilliant summary of Kawasaki Disease comes from @DrCharlie19 - a Paediatric Registar based in London

#Diagnosis

This brilliant summary ... of Kawasaki Disease ... based in London #Diagnosis ... #Management #Workup ... #Peds #Pediatrics

Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages

• Autoimmune diseases ... Adult-onset Still disease ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology

Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
• Epidemiology: 10-180/100,000, Typically Age 20-40, F:M

• Immunologic Workup ... life-threatening • Treatment ... Evolution: Chronic disease ... #Management #Summary ... #rheumatology

Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to

age, however the disease ... Diagnosis via genetic ... • Bicytopenia Treatment ... #management #treatment ... #hematology

Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
• Associated

Erythematosus - Summary ... Treatment: • ... Erythematosus #SLE #Summary ... #diagnosis #rheumatology ... #management

Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia
If prolonged or ≥ 39 C this is a

Treatment depends ... brain injury By Association ... Anesthesiology #Anesthesia ... #Checklist #Diagnosis ... #Management #Workup

Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of

hypersensitivity syndromes • HLH ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology

Polycythemia Vera (PV) - Diagnosis and Management Summary
Diagnostic Criteria:
• Elevated hemoglobin and/or hematocrit AND
•

and Management ... Summary Diagnostic ... von Willebrand disease ... #Management #Summary ... #treatment #hematology

Hemophilia - Diagnosis and Management
Diagnosis:
• Consistent bleeding history (unless screening for disease in family members

and Management ... screening for disease ... Avoid meds that ... #Management #treatment ... #hematology

Septic Arthritis - Diagnosis and Management Summary
Clinical Exam: hot, swollen, pain with passive AND active ROM

and Management ... Summary Clinical ... necrosis, Lyme disease ... viral arthritis Workup ... #Management #Summary

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