12 results
Tranexamic Acid - Indications and Pharmacology
Pharmacokinetics:
 • MOA: Inhibits plasminogen activation to plasmin & inhibits fibrinolysis
Indications and Pharmacology ... Inhibits plasminogen activation ... reduces complement activation ... diarrhea & abdominal pain ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Activation of CD8 ... IFN-y) → Excessive activation ... Phagocytosis of blood ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Flutycosine - Antibiotics Class Overview
 - 
Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
B for initial management ... severe fungal infections ... ) - Main adverse ... effects = Hematologic ... #Pharmacology #Antibiotics
IDSA Recommendations for Preventing and Treating Chagas Disease (American Trypanosomiasis) in HIV-AIDS
Preventing Clinical Disease
Indication:  Individuals
ART may prevent reactivation ... Prevention #Treatment #management ... #opportunistic ... #infections #HIVAIDS ... #pharmacology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
excessive macrophage activation ... can mimic common infections ... agent are the main ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
: Fever, flank pain ... • Infection - ... Infection occurs ... Transfusions #diagnosis #management ... #hematology #reactions
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
: Fever, flank pain ... Infection - Infection ... likely to cause infections ... Transfusion #diagnosis #management ... #hematology #reactions
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... • Fever is the main ... SLE], AOSD) • Infection ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Chagas Disease - American Trypanosomiasis - Diagnosis and Management Summary
Chagas disease (American trypanosomiasis) is an infectious
Diagnosis and Management ... trypanosomiasis) is an infectious ... family Route of infections ... Blood (platelets ... 80%) (abdominal pain
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... hemolytic anemia • Pain ... Workup: • Full Blood ... classification #hematology ... #oncology #management