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differential treatment adultonset ana antinuclear classification disease fungal hematology hemeonc hemophagocytic hlh infections infectiousdiseases lymphohistiocytosis mycoses patterns pmr polychondritis polymyalgia
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Differential Diaqnoses ... : • Infectious ... hepatitis • Pulmonary ... #management #treatment ... #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Lymphoproliferative Disorders, Infection ... , Interstitial Pulmonary ... ANA #patterns #rheumatology ... #diagnosis #differential
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... EGPA) • Auto-antibodies ... confirm DAH, r/o infection ... #differential #diagnosis ... #management #treatment
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... progressing GN • New pulmonary ... to exclude are infections ... C-ANCA) pattern: antibodies ... #rheumatology #
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
associated with other diseases ... Disease: • 10%-15% Pulmonary ... , INC risk PE, Pulmonary ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Polymyalgia Rheumatica (PMR) Diagnosis and Management Summary WHAT? • Polymyalgia rheumatica (PMR) is a common systemic inflammatory
Rheumatica (PMR) Diagnosis ... and Management ... hypothyroidism, infection ... anti-citrullinated peptide antibodies ... #Management #Rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
symptoms • Rheumatologic ... Histoplasmosis Diagnosis ... for Blastomyces antibodies ... for Coccidioides antibodies ... #Management #Infections
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Triggers: ▪ Infections ... ▪ Autoimmune diseases ... underlying trigger: Infections ... inhibitors, anti-IFN-γ antibodies ... #Management #Hematology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Behcet disease • Infections ... /EGPA • RA Diagnosis ... Anti-Matrilin-1 Ab ○ Antibodies ... Polychondritis #rheumatology ... #diagnosis #management
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