1861 results
Medications associated with neuroleptic malignant syndrome

First-generation and second-generation antipsychotics are dopamine receptor antagonists, which produce a
neuroleptic malignant syndrome ... after a single dose ... NeurolepticMalignant #Syndrome
Cushing Syndrome Testing Algorithm
INDICATIONS FOR TESTING:
 • Suspected Cushing syndrome (central obesity, muscle weakness, refractory hypertension)
Testing:
Cushing Syndrome ... Suspected Cushing syndrome ... Saliva • Low dose ... ARUPLabs #Cushing #Syndrome
Hepatorenal Syndrome - Diagnosis and Management Summary
Who gets HRS?
 • Decompensated cirrhosis
 • Typically with existing
Hepatorenal Syndrome ... vasoconstriction Dose ... cardiac output) Dose ... vasoconstrictor used Dose ... #Hepatorenal #Syndrome
Neuroleptic Malignant Syndrome - Diagnosis
Neuroleptic Malignant Syndrome is an idiosyncratic reaction to antipsychotic medications classically characterized
Neuroleptic Malignant Syndrome ... Neuroleptic Malignant Syndrome ... admin, but not dose ... Withdrawal or dose ... NMS, Serotonin Syndrome
Hepatorenal Syndrome Treatment
Volume expansion: 
 • Albumin (typical dose = 1g/kg on day 1 +/- day
Hepatorenal Syndrome ... Albumin (typical dose ... #Hepatorenal #Syndrome
Anti-IL6 Agents (Tocilizumab, Siltuximab) in COVID19

IL-6 activates T cells and macrophages, among other cell types (see
Cytokine Activation Syndrome ... /kg (suggested dose ... anti-IL6R mAb) Dose ... response to the first dose ... Total dose should
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
Stevens-Johnson Syndrome ... dopaminergic activity -> Dose-dependent ... effect - Sedation, dose-dependent
Management of Serotonin Syndrome
Identify and stop all serotoninergic medications
 • Avoid inadvertent Rx of serotoninergic meds
Management of Serotonin Syndrome ... : 12mg loading dose ... ucsdim #Serotonin #Syndrome
Penicillin Allergy Pathway for Antibiotic Prescription in Patients With Penicillin Allergy
Mild Reaction - Itching, Minor rash
denies • Use full-dose ... cephalosporin by Test Dose ... carbapenems by Test Dose ... Stevens-Johnson syndrome ... systemic symptoms syndrome
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
block • Sjogren syndrome ... polymyositis overlap syndrome ... disease- high dose