45 results
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... • Differentiate ... #Disease #differential ... #diagnosis #causes ... #hematology
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Hemolysis - Diagnostic ... hyperplasia of bone ... Anemia #Algorithm #Differential ... #Hematology #Diagnosis ... GrepMed Recommended Text
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
• Bone and joint ... Diagnosis: ... Rule out other causes ... blockers had the best ... SAPHO #Syndrome #Rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Diagnosis and Workup ... K), H. pylori test ... candidate) - Bone ... #Diagnosis #Causes ... #Workup #hematology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
decades of life Causes ... resolve within one ... pain, diarrhea, Tachycardia ... Cold #Urticaria #diagnosis ... #rheumatology #
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Pain - Diagnostic ... Like in this case ... #rheumatology # ... approach #workup #differential ... #diagnosis #arthritis
Causes of Leukocytosis and Leukopenia - Differential Diagnosis
 • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
Causes of Leukocytosis ... and Leukopenia - Differential ... Drugs, Autoimmune, Bone ... #Diagnosis #causes ... #hematology
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
• Ligament • Bone ... the subchondral bone ... #Pain #MSK #rheumatology ... approach #workup #differential ... #diagnosis #arthritis
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... Drug induced - Bone ... #Diagnosis #hematology ... #rheumatology #
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... - Differential ... Diagnosis Framework ... folate def - Bone ... #hematology