11 results
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
Diagnosis Framework ... Principles of HIV-Associated ... lobes, brainstem, cerebellum ... Periventricular regions; associated ... , limb ataxia, gait
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
HIV-Associated Neurocognitive ... Definition: HIV-Associated ... dementia Pathophysiology ... Diagnosis: MRI ... #HIV #Associated
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
- Differential Diagnosis ... endocrine: Vitamin B12 ... parainfluenza, Coxsackie, HIV ... Neoplastic: Malignancy-associated ... #Differential #Diagnosis
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
parasthesias, gait ... previously dx'd associated ... consider IM or IV ... consider other diagnosis ... Cobalamin #Deficiency #diagnosis
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... membrane into the CNS ... Pernicious anemia/B12 ... collection with EDTA Pathophysiology ... ) - Waddling gait
Seasonal Affective Disorder: Pathogenesis and clinical findings

Symptoms (included in the DSM-V) - Two Major Depressive episodes
Cravings - Weight Gain ... of year - Not associated ... SAD #Seasonal #AffectiveDisorder ... MoodDisorders #Diagnosis ... #Pathophysiology
Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation: 
1. Acidemia or Alkalemia? 
2.
- Differential Diagnosis ... glycol (present in IV ... O Oxoprolin (associated ... embolism (with associated ... acidosis: - CNS
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
of treatment of HIV ... pleural effusions, CNS ... blindness, or gait ... Other Pathogens Associated ... • Parvovirus B19
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... that results in CNS ... Check Vitamin B12 ... simplex virus, HIV ... Deficiency: - Vitamin B12
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Primary form: not associated ... Can cause TYPE IV ... nervous system (CNS ... • 8%-27% for CNS ... Cryoglobulinemia (4%-12%