125 results
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
• Congenital Myopathy ... Polymyositis • Duchenne ... Muscular Dystrophy
Duchenne Muscular Dystrophy (DMD)
The term "Muscular dystrophy" refers to a group of inherited progressive muscle disorders.
Duchenne Muscular ... Dystrophy (DMD) ... term "Muscular dystrophy ... Guillaume Duchenne ... #Duchenne #MuscularDystrophy
Gowers' Sign on Physical Exam

Seen in this patient with Duchenne muscular dystrophy (DMD)

#Gowers #Sign #PhysicalExam #neurology
this patient with Duchenne ... muscular dystrophy ... pediatrics #muscular #dystrophy ... #DMD #Duchenne
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Mitochondrial myopathy ... , Muscular dystrophy ... , Myotonic dystrophy
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Critical Illness Myopathy ... - Muscular dystrophy ... - Inflammatory myopathy ... polymyositis, necrotizing myopathy
Gowers' Sign on Physical Exam

Indicative of proximal muscle weakness in muscular dystrophy.

#Gowers #Sign #PhysicalExam #neurology #clinical
weakness in muscular dystrophy ... pediatrics #muscular #dystrophy ... #DMD #Duchenne
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
Differential diagnosis of myopathy ... #Hypothyroid myopathy ... Corticosteroid-induced myopathy ... Statin-induced myopathy ... Cocaine-induced myopathy
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
• Inflammatory myopathy ... hypothyroid-induced myopathy ... Statin-induced myopathy ... - Necrotizing myopathy ... fibers Risk of myopathy
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
rimmed vacuoles HIV myopathy ... load Drug-induced myopathy ... Gemcitabine Lupus Myopathy ... 5-15% of lupus myopathy ... Myositis #Myopathies #myopathy
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy
 • Central or peripheral neurologic disease
Mimic Inflammatory Myopathy ... Mitochondrial myopathy ... MuscleWeakness #Myopathy