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diagnosis hematology management classification elevatedmcv acidosis arteritis cobalamin deficiency elevation fatigue gca giantcell ibd lactate lactic macrocytic mcv microcytic nutrition
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Volume (MCV) - Differential ... Diagnosis Algorithm ... Increased Requirement (e.g ... #Macrocytosis #
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... Iron Deficiency (Eg ... Other • e.g ... HgbE, HgbC, etc. ... #Macrocytosis #
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Toxic Damage (e.g ... Displacement (e.g ... Megakaryopoiesis • B12 ... Foreign Surface (e.g
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (MCV) - Differential ... Diagnosis Algorithm ... Chronic Disease (e.g ... (>100 fL) • B12
Fatigue and IBD Algorithm • 40-50% patients have fatigue despite clinical remission • Risk factors: BMI,
fatigue despite clinical ... Crohn's > UC Anemia ... If persistent macrocytosis ... Receptor (sTfR) to differentiate ... /other causes •
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... dietary intake (e.g ... intrinsic factor, IF) Clinical ... organ ischemia (e.g ... other diagnosis e.g
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... by excretion (e.g ... its metabolism (e.g ... hypoxemia/Sepsis etc ... 30mmHg) - Severe anemia
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... not be subtle e.g ... very remarkable w/differential ... E.g. 80 yo ESR cutoff ... systemic complaints- anemia
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