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diagnosis management rheumatology differential classification dermatology erythematosus lupus neurology signs sle symptoms acidosis activation autoimmune cardiology cerebritis chronic cns cryofibrinogenemia
Inflammatory Joint Pain - Differential Diagnosis Algorithm Monoarticular • Gout (Podagra, Tophi) • Pseudogout • Early
• Reactive (e.g ... Enteropathic (e.g ... • Systemic Lupus ... Sicca) Syndrome ... Enteropathic (e.g
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Clinical Presentation ... Fever is the main clinical ... underlying disease (eg ... idiopathic arthritis ... • Infection (eg
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Neoplastic / Hematologic ... • Rheumatoid Arthritis ... • Drug Abuse (e.g ... Chronic Fatigue Syndrome
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
halt nail growth (e.g ... • Nephrotic syndrome ... #Secondary #dermatology ... Differential #Diagnosis #Algorithm ... #causes
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... not be subtle e.g ... E.g. 80 yo ESR cutoff ... vision changes, etc ... identifies 85 to 95% of cases
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • They can cause ... Cryoglobulins Cause ... : • Clinical triad ... tissue disorder (e.g
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... autoantibodies that will cause ... Lumbar Puncture, EEG
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... • Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... Clinical Features
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rheumatic pain Clinical ... nonerosive inflammatory arthritis ... Rule out other causes ... antiinflammatory properties e.g ... Tetracyclines etc
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
the lymphatic system ... renal failure Clinical ... of diagnosis (e.g ... Extrapulmonary: ankle arthritis ... 5-10%, nervous system
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