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Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Sequestration Disordered ... Rare • Drugs (e.g ... Connective Tissue Disorders ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- History of bleeding ... epistaxis, gingival bleeding ... function test, ANA (e.g ... (CVID, WAS), (neurologic ... #Workup #hematology
Primary Dermatological Lesions Primary lesions are physical changes in the skin considered to be caused directly by
altered colour e.g ... bruise') is where bleeding ... . e.g. psoriasis ... a generalized disorder ... #Diagnosis #Dermatology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... for secondary causes ... signs or symptoms (eg ... , skin or esophageal ... Differential #diagnosis #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
toxic aetiology: Skin ... of information (e.g ... for alternative causes ... Hepatic vascular disorder ... (e.g. ascites),
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Immunosuppression (e.g ... Autoimmune diseases (e.g ... disease: GI, neuro, cutaneous ... Malignancies (eg ... #differential #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... - Purpura - Skin ... Syndrome: • Clinical ... Henoch-Schönlein purpura) • Cutaneous ... (e.g. systemic
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... autoantibodies that will cause ... Lumbar Puncture, EEG ... Erythematosus #SLE #CNS #neurology ... #rheumatology #
Helpful Clinical Features in Evaluating Bleeding Disorders Age of onset • Neonate - in 20% of haemophilias,
Helpful Clinical ... Drug history, e.g ... and skin haemorrhage ... connective tissue, e.g ... pediatrics #diagnosis #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
chronic inflammatory disorder ... Rule out other causes ... antiinflammatory properties e.g ... Tetracyclines etc ... diagnosis #management #Dermatology
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