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diagnosis management differential anemia coagulation syndrome treatment abnormal blood prolonged pt smear activation algorithm analysis arteritis atlas bloodcell cerebritis classification
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
the PT and the aPTT ... (e.g. heparin contamination ... inhibitory drugs (e.g ... specific inhibitor (e.g ... #differential #hematology
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
factor activity (e.g ... clotting test (e.g ... PT and/or aPTT) ... Study #diagnosis #hematology ... #hematology #laboratory
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Nonspecific inhibitors e.g ... to one factor e.g ... e.g. heparin ... inhibitory drugs e.g ... #differential #hematology
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
hemolytic anemia (e.g ... Smear #Analysis #hematology ... #microscopy #interpretation ... #clinical #anemia
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... : INR/PT, aPTT(liver ... function test, ANA (e.g ... or if a primary hematologic ... #Workup #hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... Iron Deficiency (Eg ... Other • e.g ... HgbE, HgbC, etc. ... #Hematology
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
DIC is a clinical ... count, D-dimer, egg ... hemolytic #anemia #Hematology ... Pathology #Smear #Microscopy
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... mixing study (aPTT ... normal in mild cases ... hemophilia type (e.g ... Management #treatment #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... organ damage Clinical ... Treat primary cause ... INR < 2.3 - APTT ... treatment #management #hematology
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings • Subtrochanteric region spans 5 cm distally from the
Pathogenesis and clinical ... to the femur ( e.g ... remodeling -> Microscopic ... Femur #Fractures #msk ... #pathophysiology
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