30 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... differential #diagnosis #hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
of information (e.g ... for alternative causes ... Alcohol-related liver disease ... vascular disorder (e.g ... Diagnosis #Algorithm #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
PT, aPTT(liver disease ... function test, ANA (e.g ... (CVID, WAS), (neurologic ... bypass), LFT (liver disease ... #Workup #hematology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
from subclinical disease ... inflammation (eg ... been reported (eg ... of Hepatitis (eg ... Diagnosis #Management #Hepatology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... ischemic hepatitis (e.g ... use assessment (e.g ... laboratory tests (e.g ... Hepatitis #Diagnosis #Hepatology
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Clinical diagnosis ... ischemic hepatitis (e.g ... use assessment (e.g ... laboratory tests (e.g ... #hepatology #criteria
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Cerebrovascular Disease ... , PRES Pathophysiology ... autoantibodies that will cause ... Lumbar Puncture, EEG
Pisa Syndrome (pleurothotonus) on Physical Exam
A tonic flexion of the trunk of the body to one
Caused commonly ... by: - drugs (e.g ... neurodegenerative disorders (eg ... Pathophysiology: ... #neurology #posture
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
screening for disease ... with established disease ... normal in mild cases ... hemophilia type (e.g ... #hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... Lysis Syndrome: • Pathophysiology ... unless worrisome EKG ... diagnosis #management #hematology