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Dyspnea - Differential Diagnosis Framework

Cardiovascular Causes of Dyspnea:
 • Myocardium:
	- Heart failure
	- CAD/ACS
	- Valvulopathy
 • Electrical:
	-
- Tamponade Pulmonary ... Hepatopulmonary syndrome ... Myasthenia - Guillain Barre ... Transverse myelitis • Hematology ... #pulmonary
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
hyperbilirubinemia, Gilbert syndrome ... Crigler-Najjar syndrome ... Hereditary Cholestatic Syndromes ... Dubin-Johnson syndrome ... , Rotor syndrome
Causes of Erythema Nodosum - Mnemonic

NO cause found in 60% of cases
Drugs (antibiotics e.g., sulfonamides, amoxicillin)
Oral
Causes of Erythema ... Mnemonic NO cause ... Drugs (antibiotics e.g ... Sarcoidosis or Lofgren's syndrome ... Differential #Diagnosis #Dermatology
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia
Focal Hyporeflexia: 
 • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Reflex Testing - Causes ... Deep coma (any cause ... polyneuropathy (e.g ... Guillain-Barré syndrome ... Hyperthyroidism, Serotonin syndrome
Causes of Fatigue - Differential Diagnosis Algorithm
Endocrine
 • Hypo/Hyperthyroidism
 • Diabetes
 • Pituitary Insufficiency
 • Adrenal
Neoplastic / Hematologic ... Tuberculosis • Epstein-Barr ... Chronic Obstructive Pulmonary ... • Drug Abuse (e.g ... Chronic Fatigue Syndrome
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
Toxic Damage (e.g ... Displacement (e.g ... Non-lmmune: • HELLP Syndrome ... Foreign Surface (e.g ... #Hematology
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
Sepsis • Drugs (e.g ... • Gilbert's Syndrome ... Crigler-Najjar Syndromes ... Diagnosis #Algorithm #Causes ... #Hepatology #bilirubinemia
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... cardiomyopathy, Horner syndrome ... Miller Fisher Syndrome ... Electrodiagnostic studies - EMG ... #Syndrome #diagnosis
Acute Respiratory Distress Syndrome – ARDS: Clinical Cheat Sheet

An acute diffuse, inflammatory lung injury, leading to
Respiratory Distress Syndrome ... leading to increased pulmonary ... objective assessment“ (e.g ... RespiratoryDistress #Syndrome ... #CriticalCare
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... (usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g