10 results
Deciphering the SAAG - Serum to Ascites Albumin Gradient
Ascites is either made in the liver sinusoid
either made in the liver ... or not by the liver ... , Pancreatitis etc ... Matherly @liverprof #Diagnosis ... #Hepatology #SAAG
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
Causes of Ascites ... Liver disease ... - Acute fatty liver ... #Causes #diagnosis ... #differential #hepatology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
PT and/or aPTT ... Early liver disease ... e.g. heparin ... #Causes #diagnosis ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
PT and the aPTT ... (e.g. heparin contamination ... • Reduced liver ... #Causes #diagnosis ... #differential #hematology
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... of portal HTN: ascites ... (SAAG>I.I), esophageal ... : • Cardiac causes ... #causes #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... for alternative causes ... disease, Hepatic ... . ascites), Chronic ... #Algorithm #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... : INR/PT, aPTT(liver ... changes), high MCV anemia ... bypass), LFT (liver ... #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... Fibrinogen: ↓ • PT ... DIC • Severe Liver ... #Coagulation #diagnosis ... #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
- Differential Diagnosis ... Acquired: • Heparin ... discern these causes ... #Differential #Diagnosis ... #Hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
with leukopenia, anemia ... thrombocytopenia • Liver ... Hypofibrinogenemia • ↑ PT ... Activation #Syndrome #Diagnosis ... #Management #Hematology