13 results
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
Step 1: Is the PT ... K Antagonists, Heparin ... to identify the cause ... #prolonged #diagnosis ... #hematology #evaluation
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and the aPTT ... (e.g. heparin contamination ... #Causes #diagnosis ... #differential #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... e.g. heparin ... #Causes #diagnosis ... #differential #hematology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Medications - Heparin ... • Acute DIC - Septic ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... Fibrinogen: ↓ • PT ... INR < 2.3 - APTT ... #Coagulation #diagnosis ... #management #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... : INR/PT, aPTT(liver ... function test, ANA (e.g ... #Differential #Diagnosis ... #hematology
Appearance of Liver Lesions on Computed Tomography (CT) - Arterial Phase, Portal Venous Phase and Delayed
Liver #Lesions #Hepatic ... ComputedTomography #CT #radiology ... #differential #diagnosis ... #comparison #table ... #appearance #hepatology
Appearance of Liver Lesions on Various Imaging Modalities
 • Computed Tomography (CT) - Arterial Phase, Portal
Liver #Lesions #Hepatic ... CT #MRI #POCUS #radiology ... #differential #diagnosis ... #comparison #table ... #appearance #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... for alternative causes ... liver disease, Hepatic ... presentation: Hepatic ... #Algorithm #hepatology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
mixing study (aPTT ... normal in mild cases ... ) • PT/INR & von ... hemophilia type (e.g ... Management #treatment #hematology