15 results
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
PT - Prolonged ... PT - Prolonged ... Abnormal #APTT #Laboratory ... #Hematology #Diagnosis ... #Workup
Shotgun Laboratory Testing for Severe Acute Livery Injury

https://www.journalofhospitalmedicine.com/jhospmed/article/143598/hospital-medicine/ammonia-levels-and-hepatic-encephalopathy-patients-known

#TWDFNR #Testing #Laboratory #LiverInjury #Diagnosis #Workup #Hepatology #EBM #ChoosingWisely
Shotgun Laboratory ... for Severe Acute Livery ... ammonia-levels-and-hepatic-encephalopathy-patients-known ... #LiverInjury #Diagnosis ... #Workup #Hepatology
â–º
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Early liver disease ... unfractionated heparin ... Reduced liver synthesis ... #Causes #diagnosis ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... . heparin contamination ... • Reduced liver ... #Causes #diagnosis ... #differential #hematology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
Prothrombin Time (PT ... inhibitor • Liver ... elevated in: • Heparin ... Thromboplastin #laboratory ... #hematology #diagnosis
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Findings in Hepatic ... glycogen stores - Prolonged ... PT - Decreased ... #Hepatology #Laboratory ... #Diagnosis #Testing
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... disease, Hepatic ... presentation: Hepatic ... #Injury #Diagnosis ... #Algorithm #hepatology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Medications - Heparin ... ) • Advanced Liver ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... ) or metabolic liver ... Possible drug-induced liver ... Presence of atypical laboratory ... #Hepatology #AIH
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
disease to acute liver ... hepatocellular pattern of liver ... , AIH diagnosis ... Necrosis) If mild laboratory ... #Hepatology